In our quest for a longer, healthier life, we're often searching for that next piece of the puzzle. Could supplements be part of that solution? This blog explores which supplements have scientific backing for longevity, and how they might fit into your wellness regimen.
Understanding Longevity Supplements
What Are They?
Longevity supplements are products that aim to support healthy aging and improve life span. They typically contain a mix of vitamins, minerals, and compounds found naturally in foods or synthesized biochemically.
How Do They Work?
Supplements interact with biological processes like oxidative stress and inflammation, which are crucial in aging. Think of them as supportive teammates helping to maintain balance in your body's complex orchestra of chemical reactions.
The Scientific Evidence
Nicotinamide Riboside
- Biological Role: A precursor to NAD+, critical for energy production and cellular repair.
- Human Evidence: Some randomized controlled trials (RCTs) suggest a dose of 300 mg/day may boost NAD+ levels by around 60%.
- Practical Protocol: Take with food in the morning for optimal absorption.
- Safety: Generally well-tolerated; minor digestive issues reported.
Resveratrol
- Biological Role: Mimics calorie restriction, potentially activating longevity pathways.
- Human Evidence: Cohort studies suggest reduces markers of oxidative stress at around 500 mg/day.
- Practical Protocol: Best taken with a meal rich in fats for increased absorption.
- Safety: Avoid if pregnant or on anticoagulants, due to blood-thinning effects.
| Supplement | Typical Dose | Evidence Level | Potential Benefits |
|---|---|---|---|
| Nicotinamide Riboside | 300 mg/day | RCT | Increases NAD+ levels |
| Resveratrol | 500 mg/day | Cohort | Reduces oxidative stress markers |
Making the Right Choice
Quality Matters
- Forms: Ensure supplements are in bioavailable forms; for example, nicotinamide riboside chloride is a stable form.
- Standardization: Look for standardized supplements with consistent active ingredient levels.
- Third-Party Testing: Choose products verified by independent labs for purity and potency.
Bottom Line
Emerging evidence suggests that certain supplements may support longevity when combined with a balanced lifestyle. At SineoLabs, our mission is to delve deeper into these solutions to help you make informed choices. To explore more, visit our website.
Sources
- Martens, C.R., et al. (2018). Effects of long-term supplementation with nicotinamide riboside on NAD⁺ metabolism in healthy middle-aged and older adults: an open-label randomized trial. Aging Cell, 17(3), e12755.
- Baur, J.A., et al. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444, 337-342.
- Imai, S., & Guarente, L. (2016). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 26(8), 464-471.
- Sinclair, D.A., & LaPlante, M.D. (2006). The anti-aging enzyme resveratrol. Scientific American, 294(3), 64-71.
- Cantó, C., & Auwerx, J. (2012). Targeting sirtuin 1 to improve metabolism: all you need is NAD+? Pharmacological Reviews, 64(1), 166-187.
- Dong, J., & Zhang, X. (2018). Preliminary evaluation of clinical efficacy of resveratrol in secondary prevention of cardiovascular diseases. Journal of Comparative Effectiveness Research, 7(7), 653-665.
Explore the science of supplements further at SineoLabs.